ABSTRACT With the controversial ethical issues on the creation of human embryos through cloning for therapeutic research, which holds more promise for medical breakthroughs that the world could ever imagine and the acknowledgement by many scientists that this biotechnology may not lead in the near future to therapies; this country report discusses the approach Singapore takes on human stem cell research, interjected with the authors’ own arguments and suggestions especially on research compensation injuries, an often neglected important issue. International comparative (...) viewpoints taken by the major countries in the world are also included in the appendix. (shrink)

This festschrift collects a number of insightful essays by a group of accomplished Christian scholars, all of who have either worked with or studied under Hendrik Hart during his 35-year tenure as Senior Member in Systematic Philosophy at the Institute for Christian Studies, Toronto, Canada.

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

To understand how compliance develops both in everyday and corporate environments, it is crucial to understand how different mechanisms work together to shape individuals’ (non)compliant behavior. Existing compliance studies typically focus on a subset of theories (i.e., rational choice theories, social theories, legitimacy theories, capacity theories, and opportunity theories) to understand how key variables from one or several of these theories shape individual compliance. The present study provides a first integrated understanding of compliance, rooted in complexity science, in which key (...) elements from these theories are considered simultaneously, and their relations to compliance and each other are explored using network analysis. This approach is developed by analyzing online survey data (_N_ = 562) about compliance with COVID-19 mitigation measures. Traditional regression analysis shows that elements from nearly all major compliance theories (except for social theories) are associated with compliance. The network analysis revealed groupings and interconnections of variables that did not track the existing compliance theories and point to a complexity overlooked in existing compliance research. These findings demonstrate a fundamentally different perspective on compliance, which moves away from traditional narrow, non-network approaches. Instead, they showcase a complexity science understanding of compliance, in which compliance is understood as a network of interacting variables derived from different theories that interact with compliance. This points to a new research agenda that is oriented on mapping compliance networks, and testing and modelling how regulatory and management interventions interact with each other and compliance within such networks. (shrink)

Out of the Margin is the first book to consider feminist concerns across the whole domain of economics. In recent years there has been a tremendous increase in interest on the relation between gender and economics. Feminists have found much of concern in the way the economics has written women out of its history, built its theories around masculinist values, failed to take proper account of women and their work when measuring the economy and ignored most of the policy issues (...) that press most heavily upon women. This book is a firm rejection of this marginalized position. Including contributions from leading feminist economists from the US and Europe, the book offers a richness of new insights in addressing the absence of women, both as subject and object, in the history of economic thought. Out of the Margin also explores the philosophical roots of rational economic man, power relations and conflicts within the family, the limitations of relying on secondary data, the need for new data and research, the policy implications of neo-classical economic models and the need for fundamental research in policy making. With its range and depth of coverage, this is not only an excellent introduction to the field but also indispensible for anyone looking for an in-depth analysis of gender and economics. (shrink)

Biogenic approaches investigate cognition from the standpoint of evolutionary function, asking what cognition does for a living system and then looking for common principles and exhibitions of cognitive strategies in a vast array of living systems—non-neural to neural. One worry which arises for the biogenic approach is that it is overly permissive in terms of what it construes as cognition. In this paper I critically engage with a recent instance of this way of criticising biogenic approaches in order to clarify (...) their theoretical commitments and prospects. In his critique of the biogenic approach, Fred Adams uses the presence of intentional states with conceptual content as a criterion to demarcate cognition-driven behaviour from mere sensory response. In this paper I agree with Adams that intentionality is the mark of the cognitive, but simultaneously reject his overly restrictive conception of intentionality. I argue that understanding intentionality simpliciter as the mark of the mental is compatible with endorsing the biogenic approach. I argue that because cognitive science is not exclusively interested in behaviour driven by intentional states with the kind of content Adams demands, the biogenic approach’s status as an approach to cognition is not called into question. I then go on to propose a novel view of intentionality whereby it is seen to exist along a continuum which increases in the degree of representational complexity: how far into the future representational content can be directed and drive anticipatory behaviour. Understanding intentionality as existing along a continuum allows biogenic approaches and anthropogenic approaches to investigate the same overarching capacity of cognition as expressed in its different forms positioned along the continuum of intentionality. Even if all organisms engage in some behaviour that is driven by weak intentional dynamics, this does not suggest that every behaviour of all organisms is so driven. As such, the worry that the biogenic approach is overly permissive can be avoided. (shrink)

This paper is designed to do three things while discussing the challenge of ethical behavior in organization. First, it discusses some reasons why unethical behavior occurs in organization. Secondly, the paper highlights the importance of organizational culture in establishing an ethical climate within an organization. Finally, the paper presents some suggestions for creating and maintaining an ethically-oriented culture.

The institutionalization of ethics is an important task for today's organizations if they are to effectively counteract the increasingly frequent occurrences of blatantly unethical and often illegal behavior within large and often highly respected organizations. This article discusses the importance of institutionalizing organizational ethics and emphasizes the importance of several variables (psychological contract, organizational commitment, and an ethically-oriented culture) to the institutionalization of ethics within any organization.... institutionalizing ethics may sound ponderous, but its meaning is straightforward. It means getting ethics (...) formally and explicitly into daily business life. It means getting ethics into company policy formation at the board and top management levels and through a formal code, getting ethics into all daily decision making and work practices down the line, at all levels of employment. It means grafting a new branch on the corporate decision tree — a branch that reads right/wrong (Purcell and Weber, 1979, p. 6). (shrink)

A mark of the cognitive should allow us to specify theoretical principles for demarcating cognitive from non-cognitive causes of behaviour in organisms. Specific criteria are required to settle the question of when in the evolution of life cognition first emerged. An answer to this question should however avoid two pitfalls. It should avoid overintellectualising the minds of other organisms, ascribing to them cognitive capacities for which they have no need given the lives they lead within the niches they inhabit. But (...) equally it should do justice to the remarkable flexibility and adaptiveness that can be observed in the behaviour of microorganisms that do not have a nervous system. We should resist seeking non-cognitive explanations of behaviour simply because an organism fails to exhibit human-like feats of thinking, reasoning and problem-solving. We will show how Karl Friston’s Free-Energy Principle (FEP) can serve as the basis for a mark of the cognitive that avoids the twin pitfalls of overintellectualising or underestimating the cognitive achievements of evolutionarily primitive organisms. The FEP purports to describe principles of organisation that any organism must instantiate if it is to remain well-adapted to its environment. Living systems from plants and microorganisms all the way up to humans act in ways that tend in the long run to minimise free energy. If the FEP provides a mark of the cognitive, as we will argue it does, it mandates that cognition should indeed be ascribed to plants, microorganisms and other organisms that lack a nervous system. (shrink)

Although Next Generation Sequencing (NGS) has increased our ability to test and diagnose, its results are often not clear-cut and require a complex interpretation and negotiation process by both healthcare professionals and patients involved. In this paper, we explore how diagnoses identified through NGS are socially shaped under influence of the broader social context. Using an analytical framework stemming from the sociology of health and illness and science and technology studies, with a focus on the construction of diagnosis and the (...) role of uncertainty in medicine, we analyze the existing corpus of literature on NGS diagnostic practices. We show how in this early implementation phase of NGS, in which standardization efforts are not yet solidified, the boundary struggles around diagnoses obtained through NGS are particularly visible. We discuss the different steps in the diagnosis shaping process and what it subsequently entails to give and a receive a diagnosis using NGS. (shrink)

The recent corporate scandals in the United States have caused a renewed interest and focus on teaching business ethics. Business schools and their faculties are reexamining the teaching of business ethics and are reassessing their responsibilities to produce honest and truthful managers who live lives of integrity and ethical accountability. The authors recognize that no agreement exists among business schools and their faculties regarding what should be the content and pedagogy of a course in business ethics. However, the authors hold (...) that regardless of one’s biases regarding the content and pedagogy, the effective teaching of business ethics requires that the instructor in designing and delivering a business ethics course needs to focus particular attention on four principal questions: (1) what are the objectives or targeted learning outcomes of the course? (2) what kind of learning environment should be created? (3) what learning processes need to be employed to achieve the goals? and (4) what are the roles of the participants in the learning experience? The answers to these questions provide the foundations for any business ethics course. The answers are major determinants of the impact of a business ethics course on the thinking of students and the views on the ethical and professional accountabilities and responsibilities of managers in the workplace. (shrink)

Predictive processing theories are increasingly popular in philosophy of mind; such process theories often gain support from the Free Energy Principle —a normative principle for adaptive self-organized systems. Yet there is a current and much discussed debate about conflicting philosophical interpretations of FEP, e.g., representational versus non-representational. Here we argue that these different interpretations depend on implicit assumptions about what qualifies as representational. We deploy the Free Energy Principle instrumentally to distinguish four main notions of representation, which focus on organizational, (...) structural, content-related and functional aspects, respectively. The various ways that these different aspects matter in arriving at representational or non-representational interpretations of the Free Energy Principle are discussed. We also discuss how the Free Energy Principle may be seen as a unified view where terms that traditionally belong to different ontologies—e.g., notions of model and expectation versus notions of autopoiesis and synchronization—can be harmonized. However, rather than attempting to settle the representationalist versus non-representationalist debate and reveal something about what representations are simpliciter, this paper demonstrates how the Free Energy Principle may be used to reveal something about those partaking in the debate; namely, what our hidden assumptions about what representations are—assumptions that act as sometimes antithetical starting points in this persistent philosophical debate. (shrink)

The notion of a physiological individuals has been developed and applied in the philosophy of biology to understand symbiosis, an understanding of which is key to theorising about the major transition in evolution from multi-organismality to multi-cellularity. The paper begins by asking what such symbiotic individuals can help to reveal about a possible transition in the evolution of cognition. Such a transition marks the movement from cooperating individual biological cognizers to a functionally integrated cognizing unit. Somewhere along the way, did (...) such cognizing units simultaneously have cognizers as parts? Expanding upon the multiscale integration view of the Free Energy Principle, this paper develops an account of reciprocal integration, demonstrating how some coupled biological cognizing systems, when certain constraints are met, can result in a cognizing unit that is in ways greater than the sum of its cognizing parts. Symbiosis between V. Fischeri bacteria and the bobtail squid is used to provide an illustration this account. A novel manner of conceptualizing biological cognizers as gradient is then suggested. Lastly it is argued that the reason why the notion of ontologically nested cognizers may be unintuitive stems from the fact that our folk-psychology notion of what a cognizer is has been deeply influenced by our folk-biological manner of understanding biological individuals as units of reproduction. (shrink)

We investigate the covering numbers of some ideals on $${^{\omega }}{2}{}$$ ω 2 associated with tree forcings. We prove that the covering of the Sacks ideal remains small in the Silver and uniform Sacks model, respectively, and that the coverings of the uniform Sacks ideal and the Mycielski ideal, $${\mathfrak {C}_{2}}$$ C 2, remain small in the Sacks model.

De moderne geschiedwetenschap worstelt sinds haar ontstaan in de 19de eeuw met het probleem van het historisme. De resultaten van de moderne geschiedwetenschap werden aan het begin van de vorige eeuw met enthousiasme begroet en deden een ongekend grote belangstelling voor het verleden ontstaan. De ‘nieuwe’ historische methode, die bestond in een positivistische, empirisch-analytische aanpak, bleek in zijn toepassing echter een katalysator van een manifest relativisme in de geschiedwetenschap. De idealistische geschiedfilosofie werd erdoor ontmanteld, maar ook de geschiedenis zelf werd (...) steeds nauwkeuriger en preciezer ontleed. Wat bleef er aan samenhang en betekenis in de geschiedenis over? Het boven dit artikel afgedrukte citaat van Troeltsch geeft de kern van het probleem aan. Het is de historische problematiek van het ‘vergruisde beeld’, zoals J. Romein het eens aanduidde. In dat ‘vergruisde beeld’ is ook alles wat zin, waarde en norm heet in de geschiedenis ontbonden. Het gaat althans schuil achter massa’s feiten die zich maar niet samen lijken te willen voegen in een algemene betekenis. (shrink)

Met als hoofdgedachte dat begrip voor het gevoel en het lijden van de mens centraal moet staan, geeft een psychiater zijn inzichten over de wetenschappelijke basis van de psycho-analyse en over de bestaande psychoanalytische theorieën.

Examples of scriptural and historic militancy in Christianity and Islam are frequently compared today without sufficient attention to the complexity of the subject within each tradition. Through an examination of relevant biblical and Qur’anic materials, and of episodes in later history, this article attempts a fresh examination of violence in the two traditions. It argues that the tensions in each tradition related to violence, while similar in some ways, are quite distinct in others. In light of this, thoughts are suggested (...) on how each community may engage its respective tensions in order to work toward peace today. (shrink)

Locke & Bogin's (L&B's) main thesis can be extended to the acquisition of the phrasal vocabulary in that the acquisition of much phrasal vocabulary combines the acquisition of linguistic knowledge with pragmatics and performance and in that the apprenticeship system for such learning begins to flower in adolescence.

Nationale constitutie versus internationale jurisdictie? Voor het evenwicht tussen de staatsmachten, maar ook voor de ontwikkeling van internationaal recht, is de wijze waarop de nationale rechter zijn rol vervult van belang: gedraagt hij zich als rechtsvormer of als een rechtshandhaver? Zowel de legitimatie en vorming van het internationale recht als de handhaving van de internationale verplichtingen van de Staat op nationaal niveau zijn hiervan afhankelijk. Deze belangen worden bezien vanuit internationaal perspectief en uiteengezet aan de hand van recente jurisprudentie.

1. Cornelius Valerius en Sebastianus Foxius Morzillus als bronnen van Coornhert.

The biological sciences -- Mathematics and the physical sciences -- The arts -- The social sciences, philosophy, and religion -- Politics and the law.

The hypothesis of extended cognition (HEC) claims that the cognitive processes that materially realise thinking are sometimes partially constituted by entities that are located external to an agent’s body in its local envi- ronment. We show how proponents of HEC need not claim that an agent must have a central nervous system, or physically instantiate processes organised in such a way as to play a causal role equivalent to that of the brain if that agent is to be capable of (...) cognition. Focusing on the case of spatial memory, we make our argument by taking a close look at the striking example of Physarum Polycephalum plasmodium (i.e., slime mould) which uses self- produced non-living extracellular slime trails to navigate its environment. We will argue that the use of exter- nalized spatial memory by basal organisms like Physarum is an example of extended cognition. Moreover, it is a possible evolutionary precursor to the use of internal spatial memory and recall in animals thus demonstrating how extended cognition may have emerged early in evolutionary history. (shrink)

Turning around and changing an organization's culture does not happen by chance. The purpose of this paper is to offer insights into what is needed for an organization to successfully transform itself from a culture and experience that does not support individual ethical behavior. The recent bond trading scandal at Salomon Brothers will be used to demonstrate that a successful ethical turnaround does not just happen spontaneously. In particular, we argue that new leadership, altering policies, structure, behavior, and beliefs are (...) paramount to successfully change to an organizational culture that supports ethical behavior. Schein's five primary mechanisms available to leaders for embedding and reinforcing culture will be used to systematically analyze efforts to change Salomon Brothers' culture. (shrink)

Located at the intersection of philosophy of cognitive science and philosophy of biology, this thesis aims to provide a novel approach to understanding the strong continuity between life and mind. This thesis applies the Free Energy Framework, predictive processing and the conceptual apparatus from ecological psychology to reveal different manners in which the organizational processes and principles underlying life have been enriched so as to result in cognitive processes. By using these anticipatory cognitive frameworks this thesis unveils different forms of (...) cognition at work in surprising places and considers how such expressions of cognition are ultimately driven by various forms of environmental complexity. Importing the concepts of affordances, environmental information and perceptual medium from ecological psychology into predictive processing and the Free Energy Framework, an empirically grounded account of cognition as an anticipatory process that allows living systems to adapt to various degrees of uncertainty in their environments at distinct and yet overlapping timescales is argued for. In doing so, this thesis attempts to identify both the explanatory limits of ecological coupling accounts of perception and action, and the possible environmental conditions under which the predictive brain evolved from its decentralized non-neural predecessors as a solution to uncertainty. In contributing to a novel approach to constraining the mind, the various concepts deployed in both philosophy and cognitive science are sharpened, furthering the current debate on what cognition is and how it is related to life. (shrink)